FDA Approves Drug to Fight Canine Skin Cancer

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Postby pitbullmamaliz » June 6th, 2009, 8:52 am

Video here about Palladia - the vet they interview said it may be effective against other types of cancer as well. I'll dig up some actual articles, too.

http://www.foxnews.com/video2/video08.h ... 20,00.html
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Postby pitbullmamaliz » June 6th, 2009, 8:56 am

http://www.rttnews.com/ArticleView.aspx ... 669&SMap=1

Pfizer's Canine Cancer Drug Palladia Gets FDA Approval - Update
6/3/2009 10:44 AM ET

(RTTNews) - Wednesday, Pfizer Animal Health, a unit of Pfizer Inc. (PFE: News ), said that the U.S. Food and Drug Administration, or FDA, has approved Palladia, or toceranib phosphate, the first canine cancer therapy in the U.S.

Pfizer intends to make the product available for purchase in early 2010. Meanwhile, Pfizer will introduce Palladia to boarded specialists in the weeks and months ahead to expand the body of clinical experience with this new therapy.

Palladia tablet is indicated to treat Patnaik grade II or III recurrent cutaneous mast cell tumors with or without regional lymph node involvement.

Pfizer Animal Health estimates that 1.2 million new canine cancer cases are reported in the U.S. every year and according to the Morris Animal Foundation, cancer is a leading cause of death in dogs.

"At the completion of a Palladia clinical study, approximately 60% of dogs had their tumors disappear, shrink or stop growing. Also, we determined that dogs whose tumors responded to Palladia experienced an improved quality of life," said Cheryl London, who has helped Pfizer Animal Health's Veterinary Medicine Research & Development to develop Palladia since 2000.

PFE is trading at $14.73, down $0.25 or 1.74%, on a volume of about 10.5 million shares.

by RTT Staff Writer

For comments and feedback: contact editorial@rttnews.com
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Postby pitbullmamaliz » June 6th, 2009, 8:58 am

http://veterinarynews.dvm360.com/dvm/Ve ... 378&ref=25

FDA approves Pfizer's Palladia to treat mast-cell tumors in dogs
Jun 3, 2009
DVM NEWSMAGAZINE

Rockville, Md. -- Pfizer's Palladia (Toceranib phosphate) just received approval by the Food and Drug Administration (FDA). The drug is the first one developed specifically for the treatment of cancer in dogs, the FDA reported today.

The drug was cleared to treat canine cutaneous mast-cell tumors, a type of cancer responsible for about one out of five cases of canine skin tumors. Palladia was approved to treat tumors with or without regional lymph-node involvement.

"This cancer-drug approval for dogs is an important step forward for veterinary medicine," says FDA's Bernadette Dunham, DVM, PhD, in a prepared statement.

"Prior to this approval, veterinarians had to rely on human oncology drugs, without knowledge of how safe or effective they would be for dogs. Today's approval offers dog owners, in consultation with their veterinarian, an option for treatment of their dog's cancer."

Palladia is a tyrosine kinase inhibitor and works by killing tumor cells and by cutting off the blood supply to the tumor.

In a clinical trial, Palladia showed a statistically significant difference in tumor shrinkage when compared with an inactive substance (placebo).

The most common side effects are diarrhea, decrease or loss of appetite, lameness, weight loss and blood in the stool, the FDA reports.
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Postby plebayo » November 12th, 2009, 12:34 am

I just wanted to add this blog I found written by a veterinarian:

http://www.dogcancerblog.com/first-dog- ... not-great/

It seems Palladia isn't as awesome as claimed. Mostly however I thought the replies of readers would be helpful to those looking into Palladia because some of these people have tried it. My only complaint with the product is that I'm sure it's insanely expensive and if it only buys you 3 months and then the cancer returns I don't see how it can be much better than chemo therapy or radiation.
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Postby Suzi » November 12th, 2009, 9:46 am

This is the drug that I heard about via my Vet. You are right plebayo,,,it's not a cure, and I found an article somewhere, where someone used it and their dog bleed out internally. I guess all invasive treatment can have bad side effects on certain dogs.

Palladia will not be out to "GP" Vets until the beginning of next year...Right now only some Oncologists have access to it. The Oncologist we went and saw had access to it but still pointed us towards Chemo as if I recall right, the numbers were better regarding remission. The Dr. also stated that it is "free" until the end of this year, but when released next year,,,,the price will more than likely be sky high. Pfizer will not comment on what the cost will be yet.
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Postby Brownies Mom » November 12th, 2009, 8:13 pm

I put a lot of trust in Dr. Shawn Messonnier. I relied on his book many times to help Brownie, and help others, too. Here's what he has to say about Palladia in his blog. It fits in with what people have posted...

New Cancer Drug to Help Your Pet
October 2, 2009 on 1:16 pm | In General Posts | No Comments

A great discussion of the new chemotherapy drug Palladia by Pfizer, which has recently been licensed for treatment of mast cell tumors in dogs, was presented at the veterinary conference I attended last weekend.

This drug is a tyrosine kinase inhibitor which decreases the growth of blood vessels to the tumor and may offer a new way to treat aggressive mast cell tumors in dogs. Currently, dogs with mast cell tumors are treated with a combination of surgery, chemotherapy, radiation therapy. Nutritional supplements, herbs, and homeopathics are also important in treating pets with cancer to reduce side effects from conventional therapies and boost the pet’s immune system, helping it kill any remaining cancer cells.

Although Palladia is effective for many dogs with mast cell tumors, it is not effective for all dogs and does not necessarily replace traditional chemotherapy. As can be seen with chemotherapy, there is the potential that a tumor could become resistant to Palladia. Recent pre-release studies show that Palladia is about 37% effective for dogs with Grade III tumors that have come out of remission from other chemotherapy.

The most significant side effects seen have been gastrointestinal and included diarrhea, loss of appetite and weight loss. In most cases, these side effects can be effectively treated with medications but need to be addressed promptly to prevent more serious consequences. Some dogs will need to have modifications in the dose or dosing schedule. Palladia has also been shown to cause a decrease in the normal white blood cell count and it has been recommended that complete blood counts be monitored initially on a weekly basis. Less common side effects have included lameness, muscle cramps, changes in kidney function, changes in blood protein levels, and changes in the pet’s skin pigmentation.

The projected cost is not known, but it is expected to be fairly expensive. A similar medication for use in people with chronic granulocytic leukemia costs around $80,000 per year. It is likely most oncologists will NOT prescribe Palladia for the majority of dogs with mast cell tumors but will reserve its use for those dogs with tumors that are difficult to control with other medications or for those pets who have failed conventional chemotherapy.

The take home point-have all lumps and bumps aspirated by your veterinarian as soon as you notice them. Do NOT accept a diagnosis of “cyst” or “fatty tumor” based on the appearance or “feel” of the tumor. I have seen too many “cysts” and “fatty tumors” that upon aspiration were actually mast cell cancers. Early diagnosis is often curative without the use of chemotherapy!
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